Survival rates increased with new treatments in leukemia It was stated that leukemia, which is a type of cancer that occurs in white blood cells in the blood, ranks first among childhood cancers in terms of frequency, but survival rates have increased as a result of treatment protocols applied according to risk groups in recent years.
Dokuz Eylül University Medical Faculty Pediatric Hematology Department Lecturer Prof. Dr. Hale Ören made a statement to the AA reporter on the occasion of the 2-8 November Children with Leukemia Week.
Stating that leukemia ranks first among childhood cancers in terms of its prevalence, Ören explained that unlike adults, the majority of leukemia seen in childhood is of the "acute lymphoblastic leukemia" type.
Ören, "The prevalence of acute lymphoblastic leukemia is 3-4 per hundred thousand. It occurs especially in males and between the ages of 2-5. Acute myeloid leukemia is less common in children, constituting 20 percent of leukemias. The prevalence of this type of leukemia. it is 5-7 per million each year and its incidence is high during the first 2 years and adolescence. " gave the information.
Pointing out that no reason could be found to explain the development of leukemia in most children, Ören continued his words as follows:
"However, in some cases, leukemia may be familial or the risk factors to which the child is exposed, which predispose to leukemia may be identified. Exposure of the mother to alcohol, pesticides, topoisomerase II inhibitor foods and viral infections during the prenatal period may create a risk for leukemia.
Babies with various chromosomal abnormalities such as Down syndrome may develop leukemia. Acquired risk factors include ionizing radiation drugs, petroleum products, organic substances such as benzene, herbicides and pesticides. For the development of leukemia, the 'two hit' model is more widely accepted today; It is thought that the first event, followed by the second event, caused the genetic abnormality and ultimately the cells that initiate leukemia emerge. "
- "Bone marrow examination should be done first when leukemia is suspected"
Stating that the initial symptoms of acute leukemia are short-lived and may differ, Ören stated that patients frequently consult a physician due to anorexia, weakness, fatigue, restlessness, fever, bleeding findings, bone pain and pallor.
Ören, "Different clinical findings may develop when leukemic cells called blasts settle in organs. When leukemia is suspected, bone marrow examination should be performed first." he spoke.
Prof. Dr. Ören gave the following information about the treatment of the disease:
"In acute lymphoblastic leukemia, survival has exceeded 80% with current standard treatment. Although it varies according to different types in acute myeloid leukemia, survival is around 60%. In recent years, the survival rate of patients has increased as a result of treatment protocols applied according to risk groups. Used in conjunction with standard chemotherapy in the treatment of patients at risk, drug-resistant or relapsing leukemia